Journal
CURRENT ORGANIC CHEMISTRY
Volume 26, Issue 3, Pages 215-274Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272826666220201124008
Keywords
Heteroarenes; palladium; direct C-H bond arylation; catalysis; regioselectivity; aryl halides
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This review gives a comprehensive overview of the Pd-catalysed intermolecular direct C-H bond arylation of heteroarenes with arylating reagents. It summarizes the preparation of various arylating reagents, evaluates the practicality, versatility, and limitations of the arylation protocols, and compares the results with reactions using aryl halides as electrophiles. Mechanistic proposals are also discussed.
This unprecedented review with 322 references provides a critical up-to-date picture of the Pd-catalysed intermolecular direct C-H bond arylation of heteroarenes with arylating reagents alternative to aryl halides that include aryl sulfonates (aryl triflates, tosylates, mesylates, and imidazole-1-sulfonates), diaryliodonium salts, [(diacetoxy)iodo]arenes, arenediazonium salts, 1aryltriazenes, arylhydrazines and N'-arylhydrazides, arenesulfonyl chlorides, sodium arenesulfinates, arenesulfinic acids, and arenesulfonohydrazides. Particular attention has been paid to summarise the preparation of the various arylating reagents and to highlight the practicality, versatility, and limitations of the various developed arylation protocols, also comparing their results with those achieved in analogous Pd-catalysed arylation reactions involving the use of aryl halides as electrophiles. Mechanistic proposals have also been briefly summarised and discussed. However, data concerning Pd-catalysed direct C-H bond arylations involving the C-H bonds of aryl substituents of the examined heteroarene derivatives have not been taken into account.
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