Recent Advances in the Synthesis of Benzothiazole and its Derivatives

Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.

Automated summary

Benzothiazole derivatives have been extensively studied in the fields of synthetic and medicinal chemistry due to their significant pharmaceutical properties. These compounds exhibit a wide range of biological activities, including anti-inflammatory, anticancer, and antibacterial effects. This review discusses various reaction methods for the synthesis of different benzothiazole derivatives.