Journal
CURRENT ORGANIC CHEMISTRY
Volume 26, Issue 4, Pages 343-347Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272826666220214110118
Keywords
Domino/cascade reaction; multicomponent reaction; thiazole; thiazoline; fused-thiazole; anticancer; thiazolo-androstenone; isothiazole
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Funding
- National Institute of General Medical Sciences (NIGMS) from the National Institutes of Health [P20 GM103429]
- Winthrop P. Rockefeller Cancer Institute at the University of Arkansas for Medical Sciences (UAMS), Little Rock, USA
- Arkansas Biosciences Institute (ABI) mini-grant
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Recent advances in the synthesis of thiazole compounds using domino/cascade and multicomponent approaches have been summarized in this perspective.
Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported over the years to synthesize its derivatives. In this perspective, recent advances in the synthesis of thiazole compounds by using domino/cascade and multicomponent approaches have been summarized.
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