The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions

beta-Hydroxybutyl acid (DOHB), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially Alzheimer's dementia (AD), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histone acetylation, affecting the metabolism of A beta and Tau proteins, inhibiting inflammation and lipid metabolism, and regulating intestinal microbes. Based on the above findings, clinical drug development in AD has begun to focus on DOHB.Y

Automated summary

Beta-Hydroxybutyl acid plays a crucial role in the pathogenesis of cognitive disorders and Alzheimer's dementia, leading to a focus on this substance in the development of clinical drugs for AD.