Rodent models based on endolysosomal genes involved in Parkinson's disease

Genes associated with endolysosomal function have been recently associated with familial Parkinson's disease and described as risk factors for sporadic cases. This indicates that deficits in this pathway predispose to parkinsonism. To better understand the role of these genes in disease development, rodent models have been created by targeting genes playing a role in endolysosomal function, such as LRRK2, DNAJC6, review the latest findings describing parkinsonian features in these animal models secondary to endolysosomal dysfunction. Also, we provide suggestions for further development and application of these animal models to better understand the contribution of endolysosomal dysfunction in Parkinson's disease and provide novel models for testing therapeutic approaches.

Automated summary

Genes associated with endolysosomal function have been found to increase the risk of Parkinson's disease. Rodent models have been created to study the role of these genes in disease development and have shown parkinsonian features related to endolysosomal dysfunction. These animal models provide insights into the contribution of endolysosomal dysfunction in Parkinson's disease and can be used for testing therapeutic approaches.