4.5 Review

Bidirectional sensory neuron-immune interactions: a new vision in the understanding of allergic inflammation

Journal

CURRENT OPINION IN IMMUNOLOGY
Volume 72, Issue -, Pages 111-118

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2021.03.012

Keywords

-

Categories

Funding

  1. Societe Francaise de Dermatologie (SFD)
  2. Societe Francaise d'Allergologie (SFA)
  3. European Research Council [802041]
  4. INSERM ATIP-Avenir program
  5. European Research Council (ERC) [802041] Funding Source: European Research Council (ERC)

Ask authors/readers for more resources

Peripheral neurons play a crucial role in transmitting sensations and regulating type 2 immune responses and allergic inflammation. Neurons can express receptors previously thought to be exclusive to the immune system, and interact with immune cells to modulate their activation status during allergic inflammation.
Peripheral neurons (including sensory neurons) are ubiquitously distributed in all tissues, particularly at the interface with the environment. The primary function of sensory neurons is the transmission of sensations of temperature, pain and itch to elicit appropriate behavioral responses. More recently, sensory neurons have emerged as potent regulators of type 2 immune responses and allergic inflammation. There is increasing evidence showing that neurons can express receptors previously thought to be restricted to the immune compartment. In addition, certain subtypes of immune cells (e.g. mast cells, ILC2s or macrophages) also express specific neuroreceptors that provide them with the capacity to integrate neuron-derived signals and modulate their activation status during the development of allergic inflammation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available