Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 72, Issue -, Pages 139-147Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2021.04.003
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Funding
- Fondation de la Recherche Medicale (France)
- Ligue Contre le Cancer-Equipe Labelisee (France)
- Institut National de la Sante et de la Recherche Medicale (France)
- French Foundation of Rare Diseases (France)
- Agence Nationale de Recherche ANR (France) [ANR-14-CE14-0028-01, ANR-18-CE15-0025-01, ANR-10-IAHU-01]
- Institut National du Cancer (France) [PLBIO20-121]
- Societe Francaise de Lutte contre les Cancers et Leucemies de l'Enfant et de l'Adolescent, AREMIG (France)
- Federation Enfants et Sante (France)
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0028, ANR-18-CE15-0025] Funding Source: Agence Nationale de la Recherche (ANR)
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This study discusses the specific molecular and cellular components involved in the immune control of EBV-infected cells, with a focus on 'atypical' EBV infections.
Epstein-Barr virus infection is the most common viral latent infection in humans and represents one prototypical model to study immunity to viral infections. In that respect, inborn errors of immunity (IEIs) or primary immunodeficiencies (PIDs) predisposing to severe and chronic EBV infections provide peculiar examples to decipher-specific molecular and cellular components involved in the immune control of EBV-infected cells. Herein, we discuss the recent knowledge and concepts arising from these studies, with a particular focus on `atypical' EBV infections when EBV enters T, NK and smooth muscle cells, instead of the common `typical' infection of B cells.
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