Related references
Note: Only part of the references are listed.Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
Nicole E. Scharping et al.
NATURE IMMUNOLOGY (2021)
A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
Shoichi Iriguchi et al.
NATURE COMMUNICATIONS (2021)
TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers
Nisha B. Nagarsheth et al.
NATURE MEDICINE (2021)
Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma
Amod A. Sarnaik et al.
JOURNAL OF CLINICAL ONCOLOGY (2021)
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity
Yugang Guo et al.
NATURE IMMUNOLOGY (2021)
The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones
Isabel C. Poschke et al.
CLINICAL CANCER RESEARCH (2020)
Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells
Connor J. Dwyer et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2020)
TCR Repertoire Changes during TIL Expansion: Clonal Selection or Drifting?
Maria Lozano-Rabella et al.
CLINICAL CANCER RESEARCH (2020)
Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies
Devikala Gurusamy et al.
CANCER CELL (2020)
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
Sri Krishna et al.
SCIENCE (2020)
T cell stemness and dysfunction in tumors are triggered by a common mechanism
Suman Kumar Vodnala et al.
SCIENCE (2019)
Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma
Noopur Raje et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
Maria R. Parkhurst et al.
CANCER DISCOVERY (2019)
MHC-II neoantigens shape tumour immunity and response to immunotherapy
Elise Alspach et al.
NATURE (2019)
Developing neoantigen-targeted T cell-based treatments for solid tumors
Tori N. Yamamoto et al.
NATURE MEDICINE (2019)
Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells
Amelie Montel-Hagen et al.
CELL STEM CELL (2019)
APhase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers
Sanja Stevanovic et al.
CLINICAL CANCER RESEARCH (2019)
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
Imran Siddiqui et al.
IMMUNITY (2019)
Tumour heterogeneity and resistance to cancer therapies
Ibiayi Dagogo-Jack et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Nikolaos Zacharakis et al.
NATURE MEDICINE (2018)
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Joseph A. Fraietta et al.
NATURE MEDICINE (2018)
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
S. L. Maude et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
Thomas Duhen et al.
NATURE COMMUNICATIONS (2018)
Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System
Raul Vizcardo et al.
CELL REPORTS (2018)
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni et al.
NATURE (2018)
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Sanjeev Mariathasan et al.
NATURE (2018)
Tumor Antigen Escape from CAR T-cell Therapy
Robbie G. Majzner et al.
CANCER DISCOVERY (2018)
Emerging Cellular Therapies for Cancer
Sonia Guedan et al.
Annual Review of Immunology (2018)
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Marc O. Johnson et al.
CELL (2018)
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
Moshe Sade-Feldman et al.
CELL (2018)
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
Lei Zhang et al.
NATURE (2018)
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
Sanja Stevanovic et al.
SCIENCE (2017)
Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer
Nathan Singh et al.
CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2017)
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Rigel J. Kishton et al.
CELL METABOLISM (2017)
'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations
Eric Tran et al.
NATURE IMMUNOLOGY (2017)
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
Jianjun Gao et al.
CELL (2016)
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Alena Gros et al.
NATURE MEDICINE (2016)
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
Eric Tran et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells
Lenka V. Hurton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
Alena Gros et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells
Sian M. Henson et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Cancer Immunotherapy Based on Mutation-Specific CD4+T Cells in a Patient with Epithelial Cancer
Eric Tran et al.
SCIENCE (2014)
Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells
Raul Vizcardo et al.
CELL STEM CELL (2013)
Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Toshinobu Nishimura et al.
CELL STEM CELL (2013)
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Paths to stemness: building the ultimate antitumour T cell
Luca Gattinoni et al.
NATURE REVIEWS CANCER (2012)
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Steven A. Rosenberg et al.
CLINICAL CANCER RESEARCH (2011)
Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1
Paul F. Robbins et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
A human memory T cell subset with stem cell-like properties
Luca Gattinoni et al.
NATURE MEDICINE (2011)
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
Christian S. Hinrichs et al.
BLOOD (2008)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
L Gattinoni et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression
JP Huang et al.
JOURNAL OF IMMUNOTHERAPY (2005)
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
ME Dudley et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: Tumor escape by antigen loss and loss of MHC expression
HT Khong et al.
JOURNAL OF IMMUNOTHERAPY (2004)
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells
CA Klebanoff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients
ME Dudley et al.
JOURNAL OF IMMUNOTHERAPY (2003)