Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 66, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2021.102097
Keywords
Transition metals; Lanthanides; Molecular probe; Bio-imaging; Biosensing
Categories
Funding
- National Natural Science Foundation of China [21571007, 21621061, 21778002, 21861162008]
- Chemistry and Chemical Engineering Guangdong Laboratory [1932002]
- Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials [2019B121205002]
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Biological imaging and biosensing techniques have greatly contributed to advances in chemical biology, drug discovery, disease diagnosis, and prognosis. Metal-based molecular probes show unique promise in optical bioimaging and biosensing, with advantages such as small size, strong luminescence, and high photostability.
Biological imaging and biosensing from subcellular/cellular level to whole body have enabled non-invasive visualisation of molecular events during various biological and pathological processes, giving great contributions to the rapid and impressive advances in chemical biology, drug discovery, disease diagnosis and prognosis. Optical imaging features a series of merits, including convenience, high resolution, good sensitivity, low cost and the absence of ionizing radiation. Among different luminescent probes, metal-based molecules offer unique promise in optical bioimaging and biosensing in vitro and in vivo, arising from their small sizes, strong luminescence, large Stokes shifts, long lifetimes, high photostability and tunable toxicity. In this review, we aim to highlight the design of metal-based molecular probes from the standpoint of synthetic chemistry in the last 2 years for optical imaging, covering d block transition metal and lanthanide complexes and multi modal imaging agents.
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