Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 73, Issue -, Pages 78-83Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2021.06.003
Keywords
Muscle stem cell; Cell adhesion; Satellite cell; Stem cell niche; Cadherin; Skeletal muscle
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Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH [AR070231]
- Training Program in Stem Cell Research from the New York State Department of Health [NYSTEM-C32561GG]
- NIH [T32 HD075735]
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This article discusses the importance of direct contact between muscle stem cells and their neighbors, emphasizing the impact of changes in the niche during quiescence and injury on cell proliferation, self-renewal, and differentiation.
Muscle stem cells (also called satellite cells or SCs) rely on their local niche for regulatory signals during homeostasis and regeneration. While a number of cell types communicate indirectly through secreted factors, here we focus on the significance of direct contact between SCs and their neighbors. During quiescence, SCs reside under a basal lamina and receive quiescence-promoting signals from their adjacent skeletal myofibers. Upon injury, the composition of the niche changes substantially, enabling the formation of new contacts that mediate proliferation, self-renewal, and differentiation. In this review, we summarize the latest work in understanding cell-cell contact within the satellite cell niche and highlight areas of open questions for future studies.
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