Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 72, Issue -, Pages 48-53Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.10.006
Keywords
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Funding
- European Union [842578]
- US National Institutes of Health [NS084030]
- Dr. Miriam and Sheldon G. Adelson Medical Foundation
- Wings for Life
- European Research Council [ERC-2015-CoG HOW2WALKAGAIN 682999]
- Swiss National Science Foundation [310030_185214, 310030_192558, PZ00P3_185728]
- ALARME Foundation
- Swiss National Science Foundation (SNF) [310030_192558, 310030_185214, PZ00P3_185728] Funding Source: Swiss National Science Foundation (SNF)
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Despite the lack of treatment for spinal cord injury, research in recent decades has made strides in mechanism-based repair strategies. Future complete repair may rely on cataloguing the molecular signatures and growth requirements of different neuron subpopulations.
Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to repair the injured spinal cord. Evidence gathered over the last several decades has provided mechanistic information on the complex cascade of events following traumatic spinal cord injury and this is paving the way towards mechanism based repair strategies. In this review, we summarize state-of-the-art biological and engineering repair strategies and posit that complete repair will be dependent on cataloguing the molecular signatures and growth requirements of the different neuron subpopulations in the brain and spinal cord.
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