Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 73, Issue -, Pages 253-262Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.08.019
Keywords
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Funding
- European Research Council [ERC-2016-COG-726061]
- FSE/POCH (Fundo Social Europeu atraves do Programa Operacional do Capital Humano) [PD/169/2013, NORTE-08-5369-FSE-000037]
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This review discusses the strategies of regulating vascularization in cutaneous wound healing through biomaterial-based and cell-based approaches, highlighting the importance of considering the temporal features of the healing process and different types of wounds beyond the contribution to regulate vascularization.
Cutaneous healing is a highly complex process that, if altered due to, for example, impaired vascularization, results in chronic wounds or repaired neotissue of poor quality. Significant progress has been achieved in promoting neotissue vascularization during tissue repair/regeneration. In this review, we discuss the strategies that have been explored and how each one of them contributes to regulate vascularization in the context of cutaneous wound healing from two different perspectives - biomaterial-based and a cell-based approaches. Finally, we discuss the implications of these findings on the development of the 'next generation' approaches to target vascularization in wound healing highlighting the importance of going beyond its contribution to regulate vascularization and take into consideration the temporal features of the healing process and of different types of wounds.
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