4.7 Review

The limitless applications of single-cell metabolomics

Journal

CURRENT OPINION IN BIOTECHNOLOGY
Volume 71, Issue -, Pages 115-122

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.07.015

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Single-cell metabolomics is a powerful tool for high-throughput metabolic analysis at the cellular level, with great potential in decoding cell heterogeneity and identifying cell types within colonies. The development of various equipment and techniques has made SCM analysis possible for a wide range of biological samples, leading to fruitful findings in various fields such as phytology, neurology, and oncology.
Single-cell metabolomics (SCM) is currently one of the most powerful tools for performing high-throughput metabolic analysis at the cellular level. The power of single-cell metabolomics to determine the metabolic profiles of individual cells makes it very suitable for decoding cell heterogeneity. SCM bears great potential in cell type identification and differentiation within cell colonies. With the development of various equipment and techniques, SCM analysis has become possible for a wide range of biological samples. Many fields have incorporated this cutting-edge analytic tool to generate fruitful findings. This review article pays close attention to the prevalent techniques utilized in SCM and the exciting new findings and applications developed by studies in phytology, neurology, and oncology using SCM.

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