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DH Mathalon et al.
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Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: Evidence of inhibitory deficits
KS Cadenhead et al.
AMERICAN JOURNAL OF PSYCHIATRY (2000)
Expression analysis of BACE2 in brain and peripheral tissues
BD Bennett et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)