Related references
Note: Only part of the references are listed.Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189
Sahar S. Alghamdi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2021)
Neuroprotection with the cannabigerol quinone derivative VCE-003.2 and its analogs CBGA-Q and CBGA-Q-Salt in Parkinson's disease using 6-hydroxydopamine-lesioned mice
Sonia Burgaz et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2021)
Design and synthesis of new carbamates as inhibitors for fatty acid amide hydrolase and cholinesterases: Molecular dynamic, in vitro and in vivo studies
Mahdi Faal Maleki et al.
BIOORGANIC CHEMISTRY (2021)
Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease
Jack Hashem et al.
MOLECULAR NEUROBIOLOGY (2021)
Aryl N-[ω-(6-Fluoroindol-1-yl)alkyl]carbamates as Inhibitors of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and Butyrylcholinesterase: Structure-Activity Relationships and Hydrolytic Stability
Stefan Rudolph et al.
ACS OMEGA (2021)
Multitarget therapeutic approaches for Alzheimer's and Parkinson's disease: an opportunity or an illusion?
Maria Joao Matos
FUTURE MEDICINAL CHEMISTRY (2021)
New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators
Serena Montanari et al.
MOLECULES (2021)
The cannabinoid system and microglia in health and disease
Samuel S. Duffy et al.
NEUROPHARMACOLOGY (2021)
Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases
Rebecca Ferrisi et al.
PHARMACOLOGICAL RESEARCH (2021)
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system
Francesca Gado et al.
BIOORGANIC CHEMISTRY (2020)
Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders
Hui Deng et al.
ACTA PHARMACEUTICA SINICA B (2020)
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex
Changrui Xing et al.
CELL (2020)
Endocannabinoid system and adult neurogenesis: a focused review
Sergio Oddi et al.
CURRENT OPINION IN PHARMACOLOGY (2020)
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents
Rati Kailash Prasad Tripathi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Cannabinoids and the expanded endocannabinoid system in neurological disorders
Luigia Cristino et al.
NATURE REVIEWS NEUROLOGY (2020)
Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease
Han Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
Paula Morales et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
Exploration of dual fatty acid amide hydrolase and cholinesterase inhibitory potential of some 3-hydroxy-3-phenacyloxindole analogs
Rati K. P. Tripathi et al.
ARCHIV DER PHARMAZIE (2020)
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL)
Bin Zhu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Phytocannabinoids: Origins and Biosynthesis
Thies Gulck et al.
TRENDS IN PLANT SCIENCE (2020)
Therapeutic Exploitation of GPR18: Beyond the Cannabinoids? Miniperspective
Paula Morales et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration
Giuseppe Felice Mangiatordi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Beatrice Polini et al.
LIFE-BASEL (2020)
Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases
Juan A. Paez et al.
CURRENT MEDICINAL CHEMISTRY (2019)
Therapeutic Potential of Multifunctional Tacrine Analogues
Maja Przybylowska et al.
CURRENT NEUROPHARMACOLOGY (2019)
Modulation of the Cannabinoid System: A New Perspective for the Treatment of the Alzheimer's Disease
Giuseppina Talarico et al.
CURRENT NEUROPHARMACOLOGY (2019)
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief
Francesca Gado et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Cannabinoid receptor as a potential therapeutic target for Parkinson's Disease
Himadri Shekhaar Baul et al.
BRAIN RESEARCH BULLETIN (2019)
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
Giulio Poli et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor
Carlotta Granchi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities
Alessandra Bisi et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration
Jose Aguareles et al.
TRANSLATIONAL NEURODEGENERATION (2019)
Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology
Manjunath Lamani et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
Serena Montanari et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery
Francesca Gado et al.
FUTURE MEDICINAL CHEMISTRY (2019)
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo
Matthias Scheiner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Indazolylketones as new multitarget cannabinoid drugs
Pedro Gonzalez-Naranjo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
Soraya Wilke Saliba et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system
Andrea Chicca et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles
Dominik Dolles et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
Laura A. McAllister et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy
Carmen Navarrete et al.
JOURNAL OF NEUROINFLAMMATION (2018)
[18F]FMPEP-d2 PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease
Jatta S. Takkinen et al.
NEUROBIOLOGY OF AGING (2018)
Emerging strategies targeting CB2 cannabinoid receptor: Biased agonism and allosterism
Paula Morales et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure
Patricia Rivera et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
Justin S. Cisar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors
Jumpei Aida et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Mathias Jucker et al.
NATURE NEUROSCIENCE (2018)
New approaches and challenges to targeting the endocannabinoid system
Vincenzo Di Marzo
NATURE REVIEWS DRUG DISCOVERY (2018)
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies
Francesco Spinelli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis
Pasquale Annunziata et al.
JOURNAL OF NEUROIMMUNOLOGY (2017)
Crystal structures of agonist-bound human cannabinoid receptor CB1
Tian Hua et al.
NATURE (2017)
Contrasting effects of selective MAGL and FAAH inhibition on dopamine depletion and GDNF expression in a chronic MPTP mouse model of Parkinson's disease
Noemi Pasquarelli et al.
NEUROCHEMISTRY INTERNATIONAL (2017)
GPR55: A therapeutic target for Parkinson's disease?
Marta Celorrio et al.
NEUROPHARMACOLOGY (2017)
(Indolylalkyl) piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH)
Helmut Dahlhaus et al.
MEDCHEMCOMM (2017)
Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target
Tommaso Cassano et al.
FRONTIERS IN NEUROSCIENCE (2017)
Sativex in the management of multiple sclerosis-related spasticity: An overview of the last decade of clinical evaluation
Sabrina Giacoppo et al.
MULTIPLE SCLEROSIS AND RELATED DISORDERS (2017)
Functional selectivity and dualsteric/bitopic GPCR targeting
Ramona Schrage et al.
CURRENT OPINION IN PHARMACOLOGY (2017)
Polypharmacology of Approved Anticancer Drugs
Ivano Amelio et al.
CURRENT DRUG TARGETS (2017)
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2R Ligands To Combat Neurodegenerative Disorders
Dominik Dolles et al.
CHEMMEDCHEM (2016)
Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease
Marta Celorrio et al.
BRAIN BEHAVIOR AND IMMUNITY (2016)
Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists
Mojgan Aghazadeh Tabrizi et al.
CHEMICAL REVIEWS (2016)
Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update
Paula Morales et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2016)
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents
Serena Montanari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis
Paula Morales et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Role of neuroinflammation in neurodegenerative diseases
Wei-Wei Chen et al.
MOLECULAR MEDICINE REPORTS (2016)
Type-2 cannabinoid receptors in neurodegeneration
Tiziana Bisogno et al.
PHARMACOLOGICAL RESEARCH (2016)
Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction
Maria Rodriguez-Munoz et al.
ONCOTARGET (2016)
VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease
Javier Diaz-Alonso et al.
SCIENTIFIC REPORTS (2016)
The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways
Carmen del Rio et al.
SCIENTIFIC REPORTS (2016)
New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds
Martin Nimczick et al.
CHEMMEDCHEM (2015)
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands
Simone Bertini et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)
Alessio Lodola et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2015)
Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue
Noemi Pasquarelli et al.
NEUROPHARMACOLOGY (2015)
Clinical Use of Cannabinoids for Symptom Control in Multiple Sclerosis
William G. Notcutt
NEUROTHERAPEUTICS (2015)
Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications
Javier Fernandez-Ruiz et al.
NEUROTHERAPEUTICS (2015)
The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer's Disease
Gaurav Bedse et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Spasticity in patients with multiple sclerosis - clinical characteristics, treatment and quality of life
P. Flachenecker et al.
ACTA NEUROLOGICA SCANDINAVICA (2014)
A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis
Gloria Hernandez-Torres et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCCB2R selective benzimidazoles reveal unexpected intrinsic properties
Martin Nimczick et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor
Valentina Lucchesi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease
Pedro Gonzalez-Naranjo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease
Gaurav Bedse et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Polypharmacology: Challenges and Opportunities in Drug Discovery
Andrew Anighoro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Multitarget Cannabinoids as Novel Strategy for Alzheimer Disease
Pedro Gonzalez-Naranjo et al.
CURRENT ALZHEIMER RESEARCH (2013)
CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients
Maite Solas et al.
NEUROBIOLOGY OF AGING (2013)
Motor and Non-Motor Features of Parkinson’s Disease – A Review of Clinical and Experimental Studies
Marcelo M.S. Lima et al.
CNS & Neurological Disorders-Drug Targets (2012)
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
Stefano Rizzo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Synthesis and Pharmacological Evaluation of 2,4-Dinitroaryldithiocarbamate Derivatives as Novel Monoacylglycerol Lipase Inhibitors
Coco N. Kapanda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure-Activity Relationship of a New Series of Reversible Dual Monoacylglycerol Lipase/Fatty Acid Amide Hydrolase Inhibitors
Jose A. Cisneros et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
Ana Maria Martin-Moreno et al.
JOURNAL OF NEUROINFLAMMATION (2012)
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment
A. Minarini et al.
NEUROPHARMACOLOGY (2012)
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?
Angela Rampa et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
Rongqing Chen et al.
CELL REPORTS (2012)
Biochemistry of Amyloid β-Protein and Amyloid Deposits in Alzheimer Disease
Colin L. Masters et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The history of the cholinergic hypothesis
Antonio Contestabile
BEHAVIOURAL BRAIN RESEARCH (2011)
Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice
Bin Pan et al.
JOURNAL OF NEUROSCIENCE (2011)
ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL PROTECTS NEURONS AGAINST β-AMYLOID INSULTS
X. Chen et al.
NEUROSCIENCE (2011)
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
Ming Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution
Celine Schalk-Hihi et al.
PROTEIN SCIENCE (2011)
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
Daniel K. Nomura et al.
SCIENCE (2011)
Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling
Geoffray Labar et al.
CHEMBIOCHEM (2010)
Cannabinoid Receptors and Endocannabinoids: Role in Neuroinflammatory and Neurodegenerative Disorders
Tiziana Bisogno et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling
G. Labar et al.
CURRENT MEDICINAL CHEMISTRY (2010)
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Jos H. M. Lange et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Structural Basis for Human Monoglyceride Lipase Inhibition
T. Bertrand et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System
Pranab K. Chanda et al.
MOLECULAR PHARMACOLOGY (2010)
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Joel E. Schlosburg et al.
NATURE NEUROSCIENCE (2010)
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
R. G. Pertwee et al.
PHARMACOLOGICAL REVIEWS (2010)
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors
A. R. King et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
The endocannabinoid system as a target for the treatment of motor dysfunction
Javier Fernandez-Ruiz
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors
Alvin R. King et al.
CHEMISTRY & BIOLOGY (2009)
Cannabinoids and Parkinson's Disease
Moises Garcia-Arencibia et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2009)
Endocannabinoids in the Treatment of Mood Disorders: Evidence from Animal Models
Francis Rodriguez Bambico et al.
CURRENT PHARMACEUTICAL DESIGN (2009)
Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors
Coco N. Kapanda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Synthesis and in Vitro Evaluation of N-Substituted Maleimide Derivatives as Selective Monoglyceride Lipase Inhibitors
Nicolas Matuszak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z. Long et al.
NATURE CHEMICAL BIOLOGY (2009)
Endocannabinoid-Mediated Control of Synaptic Transmission
Masanobu Kano et al.
PHYSIOLOGICAL REVIEWS (2009)
CB2 cannabinoid receptors: new vistas
K. Mackie et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
The endocannabinoid system in brain reward processes
M. Solinas et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Benzofuran-based hybrid compound's for the inhibition of cholinesterase activity, β amyloid aggregation, and Aβ neurotoxicity
Stefano Rizzo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo
Serena Pasquini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling
Geoffray Labar et al.
CHEMBIOCHEM (2007)
Cannabinoid pharmacology: the first 66 years
RG Pertwee
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Endocannabinoids and β-amyloid-induced neurotoxicity in vivo:: effect of pharmacological elevation of endocannabinoid levels
M. van der Stelt et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
Ana Castro et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Designed multiple ligands. An emerging drug discovery paradigm
R Morphy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
An endocannabinoid mechanism for stress-induced analgesia
AG Hohmann et al.
NATURE (2005)
Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes
SM Saario et al.
CHEMISTRY & BIOLOGY (2005)
Structure and function of fatty acid amide hydrolase
MK McKinney et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2005)
Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1β-stimulated human astrocytes
WS Sheng et al.
GLIA (2005)
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala
AI Gulyas et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors:: Synthesis, quantitative structure-activity relationships, and molecular modeling studies
M Mor et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Neurobiology of butyrylcholinesterase
S Darvesh et al.
NATURE REVIEWS NEUROSCIENCE (2003)
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling
MH Bracey et al.
SCIENCE (2002)
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
BF Cravatt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)