4.6 Review

Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Journal

CURRENT MEDICINAL CHEMISTRY
Volume 29, Issue 16, Pages 2878-2890

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867329666220210145033

Keywords

Curcumin; thyroid gland; molecular mechanisms; hormones; thyrotropin; pituitary gland

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There is a growing body of literature on the positive therapeutic potentials of curcumin in thyroid gland disorders, with its effects on various biological pathways. This review aims to summarize the research related to curcumin's therapeutic effects on thyroid dysfunction.
There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.

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