Journal
CURRENT MEDICINAL CHEMISTRY
Volume 29, Issue 17, Pages 2995-3027Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867328666211026120335
Keywords
Cytoskeleton; thiazole; thienopyridine derivatives; thienopyrimidine; synthesis; LIM kinase
Funding
- Deanship of Scientific Research at Jouf University [DSR-2021-01-0208]
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This review provides a comprehensive survey of small organic molecules for LIM kinase inhibitors, including the discovery, SAR study results, and synthesis of these inhibitors.
LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.
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