Journal
CURRENT GENETICS
Volume 68, Issue 1, Pages 91-96Publisher
SPRINGER
DOI: 10.1007/s00294-021-01220-0
Keywords
LINC complex; KASH; Cytoskeleton; Meiosis; Budding yeast
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Funding
- Natural Science Basic Research Program of Shaanxi [2021JQ-774]
- Research Foundation of Xi'an Medical University [2020DOC17]
- Shaanxi Provincial Education Department [21JK0886, 21JK0896]
- National Natural Science Foundation of China [32070069]
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The LINC complex serves as a link between the nucleoskeleton and cytoskeleton, with SUN and KASH proteins playing key roles in transmitting forces across the nuclear envelope. Research in budding yeast has led to the identification of a telomere-associated LINC complex, providing insights into potential LINC variants in other eukaryotes.
The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex across the nuclear envelope and has maintained its general assembly mode throughout evolution. SUN and KASH proteins, which are the major components of LINC complex, interact with each other in the nuclear lumen to transmit forces across the nuclear envelope and have diverse functions. However, research of LINC complex in budding yeast has been limited due to the lack of identification of a canonical KASH protein and a cytoskeleton factor. Here, we review recent findings that addressed these puzzles in budding yeast. We highlight the distinct assembly model of the telomere-associated LINC complex in budding yeast, which could be beneficial for identifying LINC variants in other eukaryotes.
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