4.4 Review

A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer's Disease

Bhupinder Kumar et al.

Summary: Alzheimer's disease is a complex neurological disorder with multiple pathological factors involved. The use of single-target drugs has been unsuccessful in treating the disease, highlighting the importance of multi-target-directed ligands as a potential therapeutic approach.

CURRENT MEDICINAL CHEMISTRY (2022)

Review Chemistry, Medicinal

Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure-Activity Relationships

Ravi Ranjan Kumar et al.

Summary: Depression is a major cause of global disability, with many antidepressant drugs on the market containing a piperazine substructure. Piperazine plays a significant role in the development of novel antidepressants, contributing to their design and development.

CHEMMEDCHEM (2021)

Review Chemistry, Physical

Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review

Karanvir Singh et al.

Summary: This review highlights the role of nitrogen-based heterocyclics in the development of antidepressant compounds, discussing how molecules with different structural features exert their effects via multiple mechanisms. Suggestions are made for further design and development of promising antidepressants using these heterocyclic moieties.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Editorial Material Clinical Neurology

Revitalizing monoamine oxidase inhibitors: a call for action

P. Ken Gillman et al.

CNS SPECTRUMS (2020)

Review Chemistry, Medicinal

Recent advancements in the development of heterocyclic anti-inflammatory agents

Sahil Sharma et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase

Bhupinder Kumar et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives

Mina Saeedi et al.

CHEMISTRY & BIODIVERSITY (2019)

Article Pharmacology & Pharmacy

Off-label uses of drugs for depression

Sigrid S. Skanland et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Chemistry, Multidisciplinary

Profiling of LINS01 compounds at human dopamine D2 and D3 receptors

Michelle F. Correa et al.

JOURNAL OF CHEMICAL SCIENCES (2019)

Review Medicine, General & Internal

A Review of Novel Antidepressants: A Guide for Clinicians

Amber E. Faquih et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2019)

Article Biochemistry & Molecular Biology

Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands

Lars Stank et al.

MEDCHEMCOMM (2019)

Editorial Material Clinical Neurology

The burden of Parkinson's disease: a worldwide perspective

Walter A. Rocca

LANCET NEUROLOGY (2018)

Review Pharmacology & Pharmacy

A Perspective on Monoamine Oxidase Enzyme as Drug Target: Challenges and Opportunities

Bhupinder Kumar et al.

CURRENT DRUG TARGETS (2017)

Article Chemistry, Medicinal

The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine

Dorota Lazewska et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors

Betul Kaya et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

Review Chemistry, Organic

Recent Advances in Piperazine Synthesis

Kristen E. Gettys et al.

SYNTHESIS-STUTTGART (2017)

Review Neurosciences

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

Marcela Cruz-Haces et al.

TRANSLATIONAL NEURODEGENERATION (2017)

Article Medicine, General & Internal

Synthesis of new piperazine compounds and investigation of their anticholinesterase effects

Yusuf Ozkay

CUKUROVA MEDICAL JOURNAL (2017)

Review Chemistry, Medicinal

Piperazine derivatives for therapeutic use: a patent review (2010-present)

Anuj K. Rathi et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

Article Biochemistry & Molecular Biology

Piperazine derivatives as iron chelators: a potential application in neurobiology

S. Abdelsayed et al.

BIOMETALS (2015)

Article Biochemistry & Molecular Biology

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl) Piperazine Derivatives

Anna M. Waszkielewicz et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2015)

Review Medicine, General & Internal

Pharmacological Treatment of Parkinson Disease A Review

Barbara S. Connolly et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Article Biochemistry & Molecular Biology

Characterization of [3H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand

Claudia Rangel-Barajas et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Pharmacology & Pharmacy

Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits

Ümide Demir Özkay et al.

Pharmacological Reports (2014)

Article Clinical Neurology

2013 Alzheimer's disease facts and figures Alzheimer's Association

William Thies et al.

ALZHEIMERS & DEMENTIA (2013)

Review Toxicology

Update on 1-benzylpiperazine (BZP) party pills

Marcia Sa Monteiro et al.

ARCHIVES OF TOXICOLOGY (2013)

Review Chemistry, Medicinal

Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection

Manjinder Singh et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors

Leyla Yurttas et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Binding Modes of Chain Arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 Receptors

Anna Bielenica et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors

Bo Song et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Substance Abuse

Piperazine compounds as drugs of abuse

M. D. Arbo et al.

DRUG AND ALCOHOL DEPENDENCE (2012)

Review Chemistry, Medicinal

Phenylpiperazine derivatives: a patent review (2006-present)

Rodolfo do Couto Maia et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2012)

Article Biochemistry & Molecular Biology

Synthesis and Biological Evaluation of Thiophene Derivatives as Acetylcholinesterase Inhibitors

Mohamed M. Ismail et al.

MOLECULES (2012)

Review Nanoscience & Nanotechnology

Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal

Jagat R. Kanwar et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

Article Chemistry, Medicinal

Potent and selective adenosine A2A receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones

Joel M. Harris et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Chemistry, Medicinal

Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors

Alexandra Gaspar et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Pharmacology & Pharmacy

Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice

Jacek Sapa et al.

PHARMACOLOGICAL REPORTS (2011)

Review Clinical Neurology

Systematic Review of Levodopa Dose Equivalency Reporting in Parkinson's Disease

Claire L. Tomlinson et al.

MOVEMENT DISORDERS (2010)

Article Multidisciplinary Sciences

Depression, Antidepressant Use and Mortality in Later Life: The Health in Men Study

Osvaldo P. Almeida et al.

PLOS ONE (2010)

Article Chemistry, Medicinal

Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect

Alka Bali et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Chemistry, Medicinal

Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives

Agnieszka Zagorska et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers

Elisabetta Martini et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues

Xiang Zhou et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

Article Chemistry, Medicinal

Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives:: A structure-activity study

D. Shyamali Wimalasena et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Clinical Neurology

Parkinson's disease: clinical features and diagnosis

J. Jankovic

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2008)

Article Multidisciplinary Sciences

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

Jyothi K. Mallajosyula et al.

PLOS ONE (2008)

Review Clinical Neurology

Benzylpiperazine: a drug of abuse?

Alice C. Johnstone et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2007)

Article Chemistry, Medicinal

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists

Lisa S. Silverman et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Review Multidisciplinary Sciences

A century of Alzheimer's disease

Michel Goedert et al.

SCIENCE (2006)

Article Chemistry, Medicinal

Indolebutylamines as selective 5-HT1A agonists

T Heinrich et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Arylpiperazine derivatives acting at 5-HT1A receptors

ML López-Rodríguez et al.

CURRENT MEDICINAL CHEMISTRY (2002)

Article Psychiatry

Excess mortality in bipolar and unipolar disorder in Sweden

U Ösby et al.

ARCHIVES OF GENERAL PSYCHIATRY (2001)