Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 63, Issue 21, Pages 5206-5230Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2021.2015680
Keywords
Anti-inflammation; antioxidant; gut microbiota; Lycium barbarum; metabolites; polysaccharides; prebiotics
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The prevalence of inflammatory bowel disease (IBD) is increasing. Goji berry, as an ancient tonic food and nutraceutical supplement, has protective effects against IBD by regulating gut microbiota and their metabolites.
The prevalence of inflammatory bowel disease (IBD) is increasing, which is concerning because IBD is a known risk factor for the development of colorectal cancer. Emerging evidence highlights environmental factors, particularly dietary factors and gut microbiota dysbiosis, as pivotal inducers of IBD onset. Goji berry, an ancient tonic food and a nutraceutical supplement, contains a range of phytochemicals such as polysaccharides, carotenoids, and polyphenols. Among these phytochemicals, L. barbarum polysaccharides (LBPs) are the most important functional constituents, which have protective effects against oxidative stress, inflammation, and neurodegeneration. Recently, the beneficial effects of goji berry and associated LBPs consumption were linked to prebiotic effects, which can prevent dysbiosis associated with IBD. This review assessed pertinent literature on the protective effects of goji berry against IBD focusing on the gut microbiota and their metabolites in mediating the observed beneficial effects.
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