Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 63, Issue 18, Pages 3168-3188Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2021.1985428
Keywords
Natural product; Alzheimer's disease; mechanisms; oxidative stress; neuroinflammation
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Alzheimer's disease (AD) is the most common form of dementia in elderly people, and natural products and bioactive compounds have potential in preventing and treating AD.
Alzheimer's disease (AD) is the most common form of dementia in elderly people with a high incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and memory impairment. Some natural products and bioactive compounds from natural sources show great potential in the prevention and treatment of AD, such as apple, blueberries, grapes, chili pepper, Monsonia angustifolia, cruciferous vegetables, Herba epimedii, Angelica tenuissima, Embelia ribes, sea cucumber, Cucumaria frondosa, green tea, Puer tea, Amanita caesarea and Inonotus obliquus, via reducing amyloid beta (A beta) deposition, decreasing Tau hyperphosphorylation, regulating cholinergic system, reducing oxidative stress, inhibiting apoptosis and ameliorating inflammation. This review mainly summarizes the effects of some natural products and their bioactive compounds on AD with the potential molecular mechanisms.
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