Azo-Schiff base derivatives of transition metal complexes as antimicrobial agents

AMR (Antimicrobial-resistant) pathogens like MRSA (Methicillin-Resistant Staphylococcus aureus) have become prodigious peril to human health in the past couple of years with the failure of various antifungals and antibiotics in treating mild to chronic mycoses and septicemia. In the grave concern for the rising contagions, Azo-Schiff Bases with dual functionality and far-ranging pharmacological potential has been considered an excellent target for antimicrobial investigations. A diversity of homocyclic and heterocyclic organic precursors has been utilized for submitting novelty in the Azo-Schiff Base Ligands (ASBLs). In addition, the d-block transition metal chelates of ASBLs with infinitely diverse features have also been synthesized and characterized exploiting the classical and advanced analytical techniques. These resourceful coordination compounds owing to their characteristic polydentate ligands with multiple coordination sites, the geometry of complexes, and redox nature of metal centres are bestowed with the structural tunability to reinvigorate their potential applications. A detailed literature survey divulged that no compendious review has yet been published on ASBL-metal derivatives. Therefore, the present study encompasses the research undertaken during the last two decennia for the development and in vitro antimicrobial screening of these prospective drug agents. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Research on Azo-Schiff Base Ligands (ASBLs) and their metal chelates has attracted attention as important targets for antimicrobial investigations, with diverse characteristics and structural tunability offering potential applications. These coordination compounds are considered promising due to their multiple functionalities and customizable structures.