Journal
COMPUTATIONAL BIOLOGY AND CHEMISTRY
Volume 94, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compbiolchem.2021.107560
Keywords
Single-nucleotide polymorphisms (SNPs); Interleukin 33 (IL-33); In silico; Computational tools
Funding
- Research Council of Kermanshah University of Medical Sciences, Iran [97167]
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IL-33 gene has been associated with a vast variety of inflammatory disorders, and identifying functional SNPs from a pool of both functional and neutral SNPs is a major challenge. This study used bioinformatics predictive tools to predict 5 potentially deleterious nsSNPs and 22 ncSNPs in the IL-33 gene for future genetic association studies.
Interleukin 33 (IL-33) is the latest member of the IL-1 cytokine family, which plays both pro - and antiinflammatory functions. Numerous Single-nucleotide polymorphisms (SNPs) in the IL-33 gene have been recognized to be associated with a vast variety of inflammatory disorders. SNPs associated studies have become a crucial approach in uncovering the genetic background of human diseases. However, distinguishing the functional SNPs in a disease-related gene from a pool of both functional and neutral SNPs is a major challenge and needs multiple experiments of hundreds or thousands of SNPs in candidate genes. This study aimed to identify the possible deleterious SNPs in the IL-33 gene using bioinformatics predictive tools. The nonsynonymous SNPs (nsSNPs) were analyzed by SIFT, PolyPhen, PROVEAN, SNP&GO, MutPred, SNAP, PhD SNP, and I-Mutant tools. The Non-coding SNPs (ncSNPs) were also analyzed by SNPinfo and RegulomeDB tools. In conclusion, our insilico analysis predicted 5 nsSNPs and 22 ncSNPs as potential candidates in the IL-33 gene for future genetic association studies.
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