Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 206, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2021.111959
Keywords
Zwitterionic polymer; Temperature sensitivity; redox-responsive; Controlled drug release
Funding
- National Science Foundation of China [51703010]
- China Postdoctoral Science Foundation [2017M623092, 2018T111008]
- Association of Science and Technology Youth Talents Invitation Project of Shaaxi Universities [20190407]
- Special Fund for Basic Scientific Research of Central College of Chang'an University [300102319206]
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Zwitterionic nanogels with temperature sensitivity and redox responsiveness show ultra-high colloidal stability and non-specific protein adsorption resistance, exhibiting a prominent inhibitory impact on tumor cells and excellent drug release behavior.
Zwitterionic polymers play an attractive role in the application of stealthy nanocarriers for their excellent antifouling property. Herein, a zwitterionic nanogel with temperature sensitivity and redox-responsive degradability prepared by copolymerization of N-vinylcaprolactam (VCL) and 2-(methacryloyloxy) ethyldimethyl-(3sulfopropyl) ammonium hydroxide (DMAPS) via aqueous precipitation polymerization. The prepared nanogels own ultra-high colloidal stability and non-specific protein adsorption resistance as a result of the incorporation of zwitterionic groups. Meanwhile, they exhibit sensitive temperature-induced swelling/collapse transition in aqueous solution and excellent redox-degradability ascribed to the presence of disulfide bonds. The nanogels loaded with anticancer drug doxorubicin (DOX) exhibit low leakage of DOX under physiological conditions (merely 23.8 % within 24 h), whereas striking release amount of DOX under reducing conditions combined with elevated temperature (93.4 % within 24 h). The measurement of cell viability showed that the cytotoxicity of blank nanogels to tumor cells (HeLa cells) was negligible, while the nanogels loaded with DOX had a prominent inhibitory impact on tumor cells.
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