A novel triazine-based covalent organic framework combined with AuNPs and reduced graphene oxide as an electrochemical sensing platform for the simultaneous detection of uric acid, dopamine and ascorbic acid

In this work, a novel triazine-based covalent organic framework (TS-COF) was constructed by the condensation of 1, 3, 5-tris-(4-aminophenyl)triazine (TAPT) and squaric acid (SA) under solvothermal condition. By in situ growth of Au nanoparticles (AuNPs) on the surface of TS-COF, the AuNPs@TS-COF composite with enhanced electroactivity was prepared successfully. After introduction of reduced graphene oxide (RGO), the constructed AuNPs@TS-COF/RGO nanocomposite modified electrode exhibited excellent conductivity and outstanding cat-alytic activity, and could be employed to determine uric acid (UA), dopamine (DA) and ascorbic acid (AA) in urine sample simultaneously, accurately and rapidly with high sensitivity, good selectivity and high stability. The detection limits of UA, DA and AA were 0.07 mu M, 0.03 mu M and 4.30 mu M (S/N = 3), respectively.

Automated summary

A novel triazine-based covalent organic framework and its composite were successfully constructed by in situ growth of gold nanoparticles on its surface, followed by introduction of reduced graphene oxide. The constructed nanocomposite modified electrode exhibited excellent conductivity and catalytic activity, allowing for simultaneous detection of uric acid, dopamine, and ascorbic acid in urine samples accurately and rapidly.