A novel electrochemical platform based on COF/La2O3/MWCNTS for simultaneous detection of dopamine and uric acid

In this present paper, a novel electrochemical sensor based on a covalent organic framework (COF) and lanthanum oxide (La2O3) and multi-wall carbon nanotubes (MWCNTS) was prepared for sensitive and selective detection of dopamine (DA) and uric acid (UA). The sensor demonstrated excellent analytical performance for DA and UA owing to the synergistic effect among large surface area of COF, highly conducting MWCNTs and highly catalytic La2O3. Particularly, the COF with a BET surface area of 1396.04 m(2)/g prepared by the Schiff base reaction between 2, 5-dibromobenzene-1, 4-dicarbaldehyde (DBTA) and 2, 4, 6-tris(4-aminophenyl)- 1, 3, 5-triazine (TAPT), significantly enhanced the adsorption and enrichment ability of the resulted modified electrode toward the target molecules. The constructed electrochemical sensor possessed low detection limits (0.039 mu M for DA and 0.024 mu M for UA) and wide linear ranges (2 similar to 450 mu M for DA and 0.4 similar to 450 mu M for UA) and could be employed to detect simultaneously the contents of DA and UA in biological and medicine samples with outstanding reproducibility, high stability as well as strong anti-interference property.

Automated summary

This paper presents a novel electrochemical sensor based on COF, La2O3, and MWCNTS for sensitive and selective detection of DA and UA. The sensor shows excellent analytical performance, low detection limits, wide linear ranges, and outstanding reproducibility, stability, and anti-interference property for simultaneous detection of DA and UA in biological and medicine samples.