Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 631, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.127677
Keywords
Pickering emulsions; Chitosan; Emulsion stability; Skin absorption; CBD; Topical drug delivery
Categories
Funding
- Associate Laboratory LSRE-LCM - FCT/MCTES (PIDDAC) [UIDB/50020/2020]
- CIMO - Centro de Investigacao de Montanha - FCT/MCTES (PIDDAC) [UIDB/00690/2020]
- Fundacao para a Ciencia e a Tecnologia (FCT)/Ministerio da Ciencia, Tecnologia e Ensino Superior (MCTES) [UIDB/50006/2020, UIDP/50006/2020]
- Foundation for Science and Technology (FCT, Portugal) [PD/BD/135085/2017]
- Portuguese Foundation for Science and Technology [SFRH/BD/144994/2019]
- FCT/MCTES-CEEC Individual 2020 Program Contract [CEECIND/01886/2020]
- Fundação para a Ciência e a Tecnologia [PD/BD/135085/2017, SFRH/BD/144994/2019] Funding Source: FCT
Ask authors/readers for more resources
The study evaluated chitosan/collagen peptides nanoparticles-stabilized Pickering emulsions as an effective carrier for the topical delivery of cannabidiol. Among them, olive oil-prepared emulsion showed good stability and long-term storage ability, which is beneficial for the topical delivery of CBD.
Pickering emulsions (PEs) are attracting increasing attention in the areas of food, cosmetic and pharmaceutical applications owing to their surfactant-free and eco-friendly nature. Herein, PEs stabilized by chitosan/collagen peptides (CH/CP) nanoparticles were assessed as green surfactant-free vehicles for the topical delivery of cannabidiol (CBD), a highly lipophilic unstable drug that is finding an increasing appeal in the cosmetic market. The influence of the oil phase volume fraction (phi) and the oil type on the emulsion properties, stability, rheological properties, as well as on the ex-vivo skin absorption of CBD was evaluated. The PE prepared with olive oil (phi = 0.6) exhibited elastic gel-like properties and demonstrated long-term stability after 5 months of storage, with a CBD content of 99.45% of the initially added amount. The skin absorption studies showed that CBD was retained in high amounts in the stratum corneum, while the CBD skin permeation was extremely low, indicating that the produced formulations are suitable as topical delivery vehicles. ATR-FTIR examination of the treated skin samples confirmed that the produced PEs were able to overcome the stratum corneum barrier. These findings suggest that the PEs stabilized with CH/CP nanoparticles provide an effective surfactant-free alternative for the topical delivery of CBD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available