Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 633, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.127791
Keywords
GO-Fe3O4-PPy; Fe3O4 @PPy-NGQDs; Doxorubicin (DOX); NIR; Photothermal chemotherapy; Drug release
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [117M232]
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Photothermal therapy (PTT) is a promising new approach for cancer treatment that utilizes nanocomposites with superior photo thermal and magnetic properties. This study demonstrates that NIR-triggered DOX release from the nanocomposites can significantly enhance the cytotoxic effects on cancer cells, indicating great potential for photothermal chemotherapy.
Photothermal therapy (PTT) is a new treatment method being developed against traditional cancer therapy methods. In this study, graphene oxide-iron oxide-polypyrrole (GO-Fe3O4-PPy) and iron oxide@polypyrrolenitrogen doped graphene quantum dots (Fe3O4 @PPy-NGQDs) ternary nanocomposites having superior photo thermal and magnetic properties were loaded with doxorubicin (DOX) anticancer drug. The loading and release of the DOX was investigated by UV-visible spectroscopy. At the end of 48 h, the cumulative release of DOX from GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX at pH 5.5 and pH 7.4 was obtained as 99.55% +/- 0.20, 48.87% +/- 0.20% and 97.88% +/- 0.45, 38.82% +/- 0.26, respectively. After a short period of time like 4 h and 8 h, NIR-triggered release of DOX was increased significantly compared to drug release without NIR. The cytotoxic effects on the 4T1 mouse breast cancer cells of GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX drug loaded nanocomposites were determined by MTT test. The increase of DOX release with NIR effect was demonstrated by both in-vitro cytotoxicity studies and confocal laser microscopy images. In summary, multifunctional GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX nanocomposites have great potential for photothermal chemotherapy.
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