Prostate-Specific Membrane Antigen Radioguided Surgery for Salvage Pelvic Lymph Node Dissection in a Man With Prostate Cancer

A 75-year-old man with evidence of recurrent prostate cancer on Ga-68-prostate-specific membrane antigen (PSMA) PET/CT after radical prostatectomy was referred to our department for Tc-99m-PSMA radioguided surgery. Intraoperatively, lymph nodes with high count rates were localized using a handheld gamma probe. High-count specimens were resected from the exact locations as reported by Ga-68-PSMA PET/CT. The total prostate-specific antigen value decreased 6 weeks after surgery. Our case shows the feasibility of radioguided surgery with Tc-99m-PSMA for salvage lymphadenectomy in prostate cancer.

Automated summary

This case demonstrates the feasibility of using Tc-99m-PSMA radioguided surgery for salvage lymphadenectomy in prostate cancer.