4.4 Article

dNLR-Based Score Predicting Overall Survival Benefit for The Addition of Platinum-Based Chemotherapy to Pembrolizumab in Advanced NSCLC With PD-L1 Tumor Proportion Score ≥50%

Related references

Note: Only part of the references are listed.
Editorial Material Oncology

VP2-2021: Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chemotherapy in first-line (1L) non-squamous non-small cell lung cancer (Nsq-NSCLC) with high PD-L1 expression using real-world data

S. Peters et al.

Summary: Except in a subgroup of patients with no smoking history, sparing the chemotherapy in first-line CIT treatment does not appear to impact survival outcomes.

ANNALS OF ONCOLOGY (2021)

Article Oncology

Clinical factors associated with shorter durable response, and patterns of acquired resistance to first-line pembrolizumab monotherapy in PD-L1-positive non-small-cell lung cancer patients: a retrospective multicenter study

Kazutaka Hosoya et al.

Summary: In NSCLC patients with PD-L1 tumor proportion scores of >= 50% who received first-line pembrolizumab, old age, poor performance status, at least 3 metastatic organs, or bone metastasis were associated with significantly shorter progression-free survival. Among patients who developed acquired resistance (AR), oligoprogressive AR was common and associated with better post-progression survival compared to non-oligoprogressive AR. Further research is needed to develop optimal treatment approaches for these patients.

BMC CANCER (2021)

Article Oncology

Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data

Elizabeth Dudnik et al.

Summary: The study compared the efficacy of pembrolizumab (P) and a combination of pembrolizumab with platinum-based chemotherapy (PCT) as first-line treatments, showing similar outcomes in patients with EGFR/ALK/ROS1 wild-type PD-L1 TPS >= 50% non-small cell lung cancer. While differences may exist in certain specific patient subgroups, overall, there were no significant differences in long-term outcomes between the two treatment strategies.

ONCOIMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Sex-associated molecular differences for cancer immunotherapy

Youqiong Ye et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Sex and Gender Influences on Cancer Immunotherapy Response

Azzurra Irelli et al.

BIOMEDICINES (2020)

Review Microbiology

Human gut microbiota/microbiome in health and diseases: a review

Eman Zakaria Gomaa

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2020)

Article Oncology

Impact of Age on Outcomes with Immunotherapy in Patients with Non-Small Cell Lung Cancer

Morgan R. L. Lichtenstein et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

Review Oncology

Sex-Based Heterogeneity in Response to Lung Cancer Immunotherapy: A Systematic Review and Meta-Analysis

Fabio Conforti et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Review Biochemistry & Molecular Biology

Contribution of Aging, Obesity, and Microbiota on Tumor Immunotherapy Efficacy and Toxicity

Regina E. M. Baiden-Amissah et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Respiratory System

Does advanced lung inflammation index (ALI) have prognostic significance in metastatic non-small cell lung cancer?

Berna Akinci Ozyurek et al.

CLINICAL RESPIRATORY JOURNAL (2018)

Article Medicine, General & Internal

Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer

L. Gandhi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Efficacy of PD-1 & PD-L1 inhibitors in older adults: a meta-analysis

Rawad Elias et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Article Cell Biology

Reduced naive CD8+ T-cell priming efficacy in elderly adults

Olivia Briceno et al.

AGING CELL (2016)

Review Oncology

Biomarkers associated with checkpoint inhibitors

G. Manson et al.

ANNALS OF ONCOLOGY (2016)

Article Medicine, General & Internal

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Martin Reck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer

Edward B. Garon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Pharmacology & Pharmacy

Immunologic and Clinical Effects of Targeting PD-1 in Lung Cancer

R. D. Harvey

CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.