Journal
CLINICAL INFECTIOUS DISEASES
Volume 75, Issue 4, Pages 673-681Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab989
Keywords
myocarditis; pericarditis; adolescents; Comirnaty; Hong Kong
Categories
Funding
- Food and Health Bureau, the Government of the Hong Kong Special Administrative Region [COVID19F01]
- Health and Medical Research Fund of Hong Kong Government [COVID19F01]
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There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose. It is recommended for Hong Kong adolescents to receive only one dose of the Comirnaty vaccine.
Background Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. Methods This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. Results Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. Conclusions There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose. There is an increased risk of acute myocarditis/pericarditis in adolescent males following Comirnaty vaccination, especially following the second dose, providing the direct evidence to support the change in recommending Hong Kong's adolescents to receive one dose of the Comirnaty vaccine.
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