Journal
CLINICAL INFECTIOUS DISEASES
Volume 75, Issue 4, Pages 719-722Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciac079
Keywords
infective endocarditis; Streptococcus pneumoniae; bacterial polysaccharide capsule; pathogenesis
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The infant with a ventricular septal defect developed infective endocarditis caused by nontypeable S. pneumoniae, attributed to a deficient capsule rather than a host immune disorder. This case highlights the role of capsule deficiency in enhancing pneumococcal fitness for causing infective endocarditis.
The Streptococcus pneumoniae capsule is regarded as indispensable in bacteremia. We report an infant with a ventricular septal defect and infective endocarditis caused by nontypeable S. pneumoniae. In-depth investigation confirmed a deficient capsule yet favored pneumococcal fitness for causing infective endocarditis, rather than a host immune disorder, as the cause of infective endocarditis in this case.
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