Journal
CLINICAL IMMUNOLOGY
Volume 232, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2021.108858
Keywords
In vitro fertilization and embryo transfer; Infertility; Progesterone-induced blocking factor; Th1/Th2; Fetal arrest
Categories
Funding
- Beijing Municipal Administration of Hos-pitals Incubating Program [PX2021054]
- Beijing Hospitals Authority' Ascent Plan [DFL20191401]
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The study found that PIBF-mediated Th1/Th2 balance plays an important role in IVF-ET outcomes, with lower PIBF and IL-4 levels but higher TNF-alpha levels and Th1/Th2 ratios in the fetal arrest group compared to the live birth group. Increased TNF-alpha/IL-4 ratio may serve as a predictive marker for fetal arrest.
The role of progesterone-induced blocking factor (PIBF)-mediated Th1/Th2 balance in delivery outcomes of in vitro fertilization and embryo transfer (IVF-ET) has not been fully elucidated. In this study, 73 infertile women with successful IVF-ET were enrolled (16 fetal arrests and 57 live births). PIBF and IL-4 levels were significantly lower in the fetal arrest group than in the live birth group (p < 0.05). TNF-alpha level and Th1/Th2 ratios were significantly higher in the fetal arrest group than in the live birth group (p < 0.05). High TNF-alpha level and Th1/Th2 ratios were risk factors for fetal arrest, whereas increased PIBF and IL-4 levels were protective factors (P < 0.05). Increased TNF-alpha/IL-4 exhibited relatively strong predictive value for fetal arrest (AUC, 0.855; sensitivity, 93.8%; specificity, 71.9%). In summary, the PIBF-mediated Th1/Th2 balance is closely correlated with delivery outcomes of IVF-ET. TNF-alpha/IL-4 may be a predictive marker of fetal arrest.
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