Journal
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
Volume 80, Issue 4, Pages 343-352Publisher
IOS PRESS
DOI: 10.3233/CH-211269
Keywords
Contrast enhanced ultrasound (CEUS); nonfunctioning; pancreatic neuroendocrine tumors (pNETs); diagnosis; pancreatic ductal adenocarcinomas (PDACs); differential
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Funding
- National Natural Science Foundation of China [82071942]
- Clinical Research Plan of SHDC [SHDC2020CR4060]
- Shanghai Municipal Science and Technology Medical Guidance Project [18411967200]
- Shanghai Pujiang Program [2020PJD008]
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This retrospective study analyzed the CEUS features of nonfunctioning pNETs and compared them with PDACs. The results showed that CEUS features are helpful for preoperative non-invasive differential diagnosis of nonfunctioning pNETs.
AIM: Preoperative suspicion of malignancy in nonfunctioning pancreatic neuroendocrine tumors (pNETs) is mostly based on tumor size. We retrospectively analyzed the contrast enhanced ultrasound (CEUS) features of a series of histopathologically proved nonfunctioning pNETs. METHODS: In this retrospective study, 37 surgery and histologically proved nonfunctioning pNETs were included. All pNETs lesions were incidentally detected by transabdominal ultrasound. B mode ultrasound (BMUS) and CEUS features were reviewed and analyzed. 52 histopathologically proved pancreatic ductal adenocarcinoma (PDACs) lesions were included as a control group. RESULTS: All nonfunctioning pNETs patients showed no typical clinical symptoms. No significant differences were observed in size, echogenicity or internal color flow imaging signal between pNETs and PDAC patients (P> 0.05). Most of nonfunctioning pNETs showed a well-defined tumor margin. The presence of pancreatic duct dilatation was less frequently observed in nonfunctioning pNETs patients (P < 0.05). After injection of ultrasound contrast agents, homogeneous enhancement was more commonly observed in nonfunctioning pNETs group (P < 0.05). During arterial phase of CEUS, most of nonfunctioning pNETs were hyper- or isoenhanced (32/37, 86.5%), whereas most of PDACs were hypoenhanced (34/52, 65.4%) (P < 0.05). Nonenhanced necrosis area was more commonly detected in PDACs (P = 0.012). CONCLUSIONS: CEUS features are helpful for preoperative non-invasive differential diagnosis of nonfunctioning pNETs, assisting further clinical decision-making process.
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