Journal
CLINICAL CHEMISTRY
Volume 67, Issue 11, Pages 1466-1482Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/clinchem/hvab165
Keywords
artificial intelligence; machine learning; laboratory medicine; supervised machine learning
Categories
Funding
- Roche Diagnostics
- BD
- Biofire
- Cepheid
- Luminex
- OpGen
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AI and ML technologies have significantly impacted laboratory medicine, but their current implementation is still in the preliminary stages. To facilitate the use of reliable and advanced ML-based technologies, further best practices need to be established, and information systems and communication infrastructure must be improved.
BACKGROUND: Modern artificial intelligence (AI) and machine learning (ML) methods are now capable of completing tasks with performance characteristics that are comparable to those of expert human operators. As a result, many areas throughout healthcare are incorporating these technologies, including in vitro diagnostics and, more broadly, laboratory medicine. However, there are limited literature reviews of the landscape, likely future, and challenges of the application of AI/ML in laboratory medicine. CONTENT: In this review, we begin with a brief introduction to AI and its subfield of ML. The ensuing sections describe ML systems that are currently in clinical laboratory practice or are being proposed for such use in recent literature, ML systems that use laboratory data outside the clinical laboratory, challenges to the adoption of ML, and future opportunities for ML in laboratory medicine. SUMMARY: AI and ML have and will continue to influence the practice and scope of laboratory medicine dramatically. This has been made possible by advancements in modern computing and the widespread digitization of health information. These technologies are being rapidly developed and described, but in comparison, their implementation thus far has been modest. To spur the implementation of reliable and sophisticated ML-based technologies, we need to establish best practices further and improve our information system and communication infrastructure. The participation of the clinical laboratory community is essential to ensure that laboratory data are sufficiently available and incorporated conscientiously into robust, safe, and clinically effective ML-supported clinical diagnostics.
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