Journal
CLINICAL & TRANSLATIONAL ONCOLOGY
Volume 24, Issue 5, Pages 809-815Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s12094-021-02759-7
Keywords
Personalized medicine; Pediatric oncology; Next generation sequencing; Onco-genomics; Molecular biomarkers; Targeted therapies
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Funding
- Bayer
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The study analyzed the current status of personalized medicine in pediatric oncology in Spain, focusing on tumor molecular studies and genomic sequencing. Despite the implementation of precision medicine in many centers in Spain, there are unevenness and lack of protocol standardization in its implementation.
The study analyzes the current status of personalized medicine in pediatric oncology in Spain. It gathers national data on the tumor molecular studies and genomic sequencing carried out at diagnosis and at relapse, the centers that perform these studies, the technology used and the interpretation and clinical applicability of the results. Current challenges and future directions to achieve a coordinated national personalized medicine strategy in pediatric oncology are also discussed. Next generation sequencing-based (NGS) gene panels are the technology used in the majority of centers and financial limitations are the main reason for not incorporating these studies into routine care. Nowadays, the application of precision medicine in pediatric oncology is a reality in a great number of Spanish centers. However, its implementation is uneven and lacks standardization of protocols; therefore, national coordination to overcome the inequalities is required. Collaborative work within the Personalized Medicine Group of SEHOP is an adequate framework for encouraging a step forward in the effort to move precision medicine into the national healthcare system.
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