4.7 Review

circRNA-miRNA-mRNA in breast cancer

Related references

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Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis

Fenglin Cai et al.

Summary: The novel circRNA hsa_circ_0000515 was found to be upregulated in breast cancer tissues and associated with poor prognosis. Silencing hsa_circ_0000515 impaired cell functions and inflammatory response, while its binding with miR-296-5p affected CXCL10 expression. Targeting hsa_circ_0000515 may be an effective strategy in combating breast cancer.

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Circular RNA Circ_0000442 acts as a sponge of MiR-148b-3p to suppress breast cancer via PTEN/PI3K/Akt signaling pathway

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Summary: This study identified the tumor-suppressive role of circ_0000442 in breast cancer for the first time and found PTEN as a novel direct target of miR-148b-3p. The regulatory role of circ_0000442/miR-148b-3p/PTEN/PI3K/Akt axis was preliminarily confirmed in breast cancer cells and mouse models. These findings provide important progress in understanding breast cancer and lay the foundation for further research on the function, diagnosis, therapy, and prognosis of circular RNAs in breast cancer.
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circGFRA1 affects the sensitivity of triple-negative breast cancer cells to paclitaxel via the miR-361-5p/TLR4 pathway

Shu-rong Zheng et al.

Summary: This study clarifies that circGFRA1 affects the sensitivity of TNBC cells to PTX via the miR-361-5p/TLR4 pathway. Knockdown of circGFRA1 can inhibit TNBC cell resistance to PTX by promoting the expression of miR-361-5p and subsequently reducing the expression of TLR4.

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Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Xuehui Wang et al.

Summary: Hsa_circ_0005273 is overexpressed in breast cancer tissues and cell lines, promoting BC progression by regulating the miR-200a-3p/YAP1 axis and inactivating the Hippo signaling pathway. Depletion of hsa_circ_0005273 inhibits tumor cell proliferation, migration, and cell cycle progression, suggesting it as a potential therapeutic target for breast cancer.

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CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA-485-3p/zinc finger E-box binding homeobox 1 axis

Chen Xie et al.

Summary: This study revealed that circ-DNMT1 and ZEB1 levels were elevated, while miR-485-3p levels were decreased in breast cancer. Knockdown of circ-DNMT1 constrained breast cancer development by modulating the miR-485-3p/ZEB1 axis.

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Circ_0008039 supports breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis

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Summary: This study demonstrated that downregulation of circ_0008039 suppressed breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis. The findings provide an important theoretical basis for the treatment of breast cancer.

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Circ_0004771 Accelerates Cell Carcinogenic Phenotypes via Suppressing miR-1253-Mediated DDAHI Inhibition in Breast Cancer

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Summary: Circ_0004771 accelerates cell carcinogenic phenotypes in breast cancer by upregulating DDAH1 expression through absorbing miR-1253. Additionally, circ_0004771 was found to be packaged into exosomes isolated from the serum of breast cancer patients. These findings suggest a promising molecular target for breast cancer treatment.

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

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CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis

Liqiang Qi et al.

Summary: This study demonstrated that circMMP11 and ZEB2 were overexpressed in BC tissues and cells, and their suppression inhibited proliferation, migration, and invasion while inducing apoptosis of BC cells. CircMMP11 was shown to regulate ZEB2 expression by targeting miR-625-5p, suggesting that circMMP11 functions as an oncogenic circRNA in BC by affecting ceRNA mechanism.

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CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18

Jiantao Wang et al.

Summary: The study showed that circTP63 is significantly upregulated in HCC tissues and cell lines, and its high expression is associated with advanced tumor stages, lymph node metastasis, and poor prognosis in HCC patients. Mechanistically, circTP63 acts as a sponge for miR-155-5p to regulate ZBTB18 expression, which is negatively correlated with the survival rate of HCC patients, highlighting a critical regulatory network in HCC progression.

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Hsa_circ_0069094 accelerates cell malignancy and glycolysis through regulating the miR-591/HK2 axis in breast cancer

Zeyu Xing et al.

Summary: The study found that circ_0069094 was upregulated in BC, associated with poor prognosis. Silencing circ_0069094 induced apoptosis, reduced proliferation, and glycolysis, while overexpression had opposite effects. Circ_0069094 was verified to regulate HK2 expression by sponging miR-591. These results suggest that circ_0069094 might serve as a prognostic biomarker and therapeutic target for BC.

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Circ-UBR1 facilitates proliferation, metastasis, and inhibits apoptosis in breast cancer by regulating the miR-1299/CCND1 axis

Linfeng Zhang et al.

Summary: Our study revealed that circ-UBR1 is upregulated in breast cancer (BC), and its silencing can inhibit BC cell proliferation, metastasis, and promote apoptosis in vitro, as well as restrain BC tumor growth in vivo. Furthermore, circ-UBR1 can sponge miR-1299, and miR-1299 inhibitor can reverse the effect of circ-UBR1 knockdown on BC cell progression, affecting CCND1 expression.

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CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway

Lei Wang et al.

Summary: CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells.

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CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer

Ya Fan et al.

Summary: The study revealed that HRD1 is significantly underexpressed in triple-negative breast cancer (TNBC) and inhibits cancer progression by inducing proteasomal degradation of Vimentin. CircNR3C2 is also downregulated in TNBC and enhances the tumor-suppressive effects of HRD1 through sponging miR-513a-3p. This circNR3C2/miR-513a-3p/HRD1/Vimentin axis negatively regulates TNBC metastasis and may serve as potential prognostic biomarkers for aggressive breast cancer.

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Hsa_circ_0025202 suppresses cell tumorigenesis and tamoxifen resistance via miR-197-3p/HIPK3 axis in breast cancer

Hongjuan Li et al.

Summary: The study revealed that hsa_circ_0025202 repressed cell tumorigenesis and tamoxifen resistance via the miR-197-3p/HIPK3 axis in breast cancer, providing a potential therapeutic strategy to overcome chemoresistance in breast cancer patients.

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CircRNA circYY1 (hsa_circ_0101187) Modulates Cell Glycolysis and Malignancy Through Regulating YY1 Expression by Sponging miR-769-3p in Breast Cancer

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