4.8 Article

ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Base-resolution models of transcription-factor binding reveal soft motif syntax

Ziga Avsec et al.

Summary: This study introduces a deep learning model, BPNet, which utilizes DNA sequences to predict base-resolution chromatin immunoprecipitation (ChIP)-nexus binding profiles of pluripotency TFs. Interpretation tools were developed to learn predictive motif representations and identify soft syntax rules for cooperative TF binding interactions. Results show that Nanog preferentially binds with helical periodicity, and TFs often cooperate in a directional manner.

NATURE GENETICS (2021)

Article Hematology

Fibrous Caps in Atherosclerosis Form by Notch-Dependent Mechanisms Common to Arterial Media Development

Carlos J. Martos-Rodriguez et al.

Summary: The study shows that Notch signaling plays a crucial role in the formation of atheromatous fibrous caps, with sequential loss and gain of Notch signaling needed to build the cap SMC population. The findings suggest that the cap forms as a neo-media that restores the connection between endothelium and subendothelial SMCs transiently disrupted in early atherogenesis.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Article Endocrinology & Metabolism

Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFR beta and bioenergetic mechanisms

Alexandra A. C. Newman et al.

Summary: The study found that stable atherosclerotic plaques are composed of cells from various origins, including smooth muscle cells, endothelial cells, and macrophages that undergo different transitions to produce myofibroblast-like cells. Additionally, it was shown that myofibroblasts derived from endothelial-to-mesenchymal transition and macrophage-to-mesenchymal transition cannot indefinitely compensate for the loss of smooth muscle cell-derived myofibroblasts. Furthermore, the transitions from smooth muscle cells to myofibroblasts are induced by PDGF and TGF-beta, while endothelial-to-mesenchymal transition is induced by interleukin-1 beta and TGF-beta.

NATURE METABOLISM (2021)

Article Medicine, Research & Experimental

Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling

Jessica Davis-Knowlton et al.

LABORATORY INVESTIGATION (2019)

Review Biochemistry & Molecular Biology

Genetics of Common, Complex Coronary Artery Disease

Kiran Musunuru et al.

Article Multidisciplinary Sciences

The single-cell transcriptional landscape of mammalian organogenesis

Junyue Cao et al.

NATURE (2019)

Article Cardiac & Cardiovascular Systems

Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade

Tinna Christersdottir et al.

EUROPEAN HEART JOURNAL (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Biochemistry & Molecular Biology

Interleukin-1 beta has atheroprotective effects in advanced atherosclerotic lesions of mice

Delphine Gomez et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

Genome-wide analysis yields new loci associating with aortic valve stenosis

Anna Helgadottir et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

Ashish Misra et al.

NATURE COMMUNICATIONS (2018)

Article Genetics & Heredity

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

Boxiang Liu et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2018)

Article Cell & Tissue Engineering

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

Agata Stryjewska et al.

STEM CELLS (2017)

Article Medicine, Research & Experimental

Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency

Christina V. Theodoris et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Biochemical Research Methods

chromVAR : inferring transcription-factor-associated accessibility from single-cell epigenomic data

Alicia N. Schep et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

Olga A. Cherepanova et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Clint L. Miller et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

Laura S. Shankman et al.

NATURE MEDICINE (2015)

Article Biochemical Research Methods

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

Pratiksha I. Thakore et al.

NATURE METHODS (2015)

Editorial Material Genetics & Heredity

HUMAN GENETICS GTEx pilot quantifies eQTL variation across tissues and individuals

Orli G. Bahcall

NATURE REVIEWS GENETICS (2015)

Article Cardiac & Cardiovascular Systems

Intravascular Imaging of Coronary Calcification and its Clinical Implications

Gary S. Mintz

JACC-CARDIOVASCULAR IMAGING (2015)

Article Biochemistry & Molecular Biology

Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration

Ya-Chieh Hsu et al.

Article Biochemistry & Molecular Biology

Identification of CAD candidate genes in GWAS loci and their expression in vascular cells

Ayca Erbilgin et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Genetics & Heredity

Large-scale association analysis identifies new risk loci for coronary artery disease

Panos Deloukas et al.

NATURE GENETICS (2013)

Letter Biochemistry & Molecular Biology

Successes of Genome-wide Association Studies

Robert J. Klein et al.

Article Biotechnology & Applied Microbiology

GREAT improves functional interpretation of cis-regulatory regions

Cory Y. McLean et al.

NATURE BIOTECHNOLOGY (2010)

Article Cell Biology

δEF1 mediates TGF-β signaling in vascular smooth muscle cell differentiation

Go Nishimura et al.

DEVELOPMENTAL CELL (2006)

Article Multidisciplinary Sciences

Mutations in NOTCH1 cause aortic valve disease

V Garg et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes

I Ovcharenko et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biochemistry & Molecular Biology

Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway

AA Postigo

EMBO JOURNAL (2003)

Article Cardiac & Cardiovascular Systems

Arterial remodeling - Mechanisms and clinical implications

MR Ward et al.

CIRCULATION (2000)