Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 40, Issue 10, Pages 1204-1223Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202100812
Keywords
Copper; Chelation assistance; C-H amination; N-Heterocycle synthesis; Cross-coupling
Categories
Funding
- National Natural Science Foundation of China [21938001, 21961160741, 22078072]
- Special Innovation Project of Guangdong Provincial Department of Education [2021KTSCX082]
- Science and Technology Plan Project of Maoming City [2020581, 2021009, 2021012]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515110346]
- Scientific Research Foundation of Guangdong University of Petrochemical Technology [517152, 2019rc053]
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This article summarizes the recent research progress in copper-catalyzed C-H amination and briefly describes the mechanisms of representative reactions, providing insights for the development of highly practical and more environmentally friendly processes.
Comprehensive Summary Nitrogen-containing compounds are ubiquitously found in the fields of organic chemistry, pharmaceuticals, agrochemicals, medicinal chemistry and functional materials. The C-H bond amination reaction is one of the most straightforward protocols in the C-N bond formation, showing step and atomic economy. As a catalyst for C-H amination reaction, copper exhibits its unique catalytic properties due to easily accessible oxidation states. The research progress of copper-catalyzed C-H amination in recent years is summarized. At the same time, reaction mechanisms are also briefly described in representative aminations to provide insights for the development prospects of highly practical and more environmentally benign processes.
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