Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles for ovalbumin delivery

Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles were disclosed for ovalbumin (OVA) delivery system. The mannose-coated polypeptide nanoparticles can induce strongest targeting and immune adjuvant effects to macrophages than those glucose/lactose-coated ones, which effectively transported OVA into cells and facilitated OVA subcellular escape from endolysosomes into cytoplasm with the assistance of UV irradiation or intracellular acidic pH. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

This study revealed the sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles as ovalbumin (OVA) delivery system. Mannose-coated polypeptide nanoparticles showed the strongest targeting and immune adjuvant effects on macrophages compared to glucose/lactose-coated ones, effectively delivering OVA into cells and facilitating OVA subcellular escape from endolysosomes into the cytoplasm with the assistance of UV irradiation or intracellular acidic pH.