Recent development in fluorescent probes based on attacking of double bond and masking of functional group

The works on the procedure of fluorescent sensors for the detection of biological analytes are extremely momentous. Among diverse analytical approaches, fluorescence is the most eye-catching due to its high sensitivity, selectivity, rapidity, robustness, ease of measurement and non-destructive approaches. Herein, we show different fluorescent probes synthesized for estimation and detection of biological analytes (H2S, SO32-/HSO3, H2O2, HOCl, HNO, ONOO-). These probes were constructed by masking the functional groups (hydroxyl and amino) of fluorophore and formation of active C=C, C=N, C=O and N=N for specific analytes. In this review we concentrate on synthesis of the probe, their photophysical properties and applications to biological studies. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

The works on fluorescent sensors for the detection of biological analytes are highly significant, offering advantages such as high sensitivity, selectivity, and rapidity. This review focuses on the synthesis of fluorescent probes and their applications in biological studies.