Metal-phenolic networks modified polyurethane as periosteum for bone regeneration

Treatment of bone defects still poses a great challenge in orthopedic clinics, and the vital role of periosteum in such processes has attracted widespread attention. However, studies focusing on the oxidative stress micro-environment with an artificial periosteum at the site of defect have been scarce. The intrinsic anti-oxidative properties and therapeutic potential for bone defects of metal-phenolic networks (MPNs) have provided a potential solution to this. Herein, we have developed a protocatechualdehyde + zinc ion (PCA+Zn-II) MPN coating on a thermoplastic polyurethane membrane with a one-pot method to fabricate a new-type of periosteum with meritorious biocompatibility and abilities of modulating oxidative stress condition and promoting osteogenesis and mineralization for better bone regeneration, which has shown to be a promising strategy for constructing artificial periosteum with various MPNs. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

Treatment of bone defects is challenging, and there is limited research on the oxidative stress micro-environment of artificial periosteum. Metal-phenolic network coatings offer a potential solution for better bone regeneration by providing good biocompatibility, modulating oxidative stress, and promoting osteogenesis.