Tuning host-guest binding model by different intramolecular alkyl chain lengths in tripodal hosts: An evidence on structure control supramolecular interactions

Supramolecular chemistry has received considerable attention in host-guest recognition. The structure-response relationship of host-guest recognition system is a meaningful issue. Herein, a series of tripodal nitrogen mustard derivatives (TMs) have been developed in this paper. By rationally design the intramolecular alkyl chain lengths of host, the host-guest binding model have been successfully tuned, which underwent a transformation from pi-pi to multiple hydrogen bonds. This process enhances the host-guest binding force and recognition efficiency. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

In this paper, a series of tripodal nitrogen mustard derivatives (TMs) were developed, and the host-guest binding model was successfully tuned by rationally designing the intramolecular alkyl chain lengths of the host. This transformation from pi-pi to multiple hydrogen bonds enhanced the host-guest binding force and recognition efficiency.