Journal
CHINESE CHEMICAL LETTERS
Volume 33, Issue 8, Pages 4057-4060Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.12.053
Keywords
Electro-reductive; C-H cyanoalkylation; Reductant-free; Quinoxalin-2(1H)-ones; Ring-opening
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Funding
- National Natural Science Foundation of China [21732002, 22077071]
- Frontiers Science Center for New Organic Matter, Nankai University [63181206]
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Here, we present a practical electro-reductive method for the direct C-H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions occur under metal-, reductant-, and reagent-free conditions, yielding synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.
Herein, we report a practical electro-reductive protocol for the direct C-H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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