Journal
CHEST
Volume 161, Issue 5, Pages 1285-1296Publisher
ELSEVIER
DOI: 10.1016/j.chest.2021.12.650
Keywords
antiphospholipid syndrome; disseminated intravascular coagulation; hematologic emergencies; hemophagocytic lymphohistiocytosis; thrombotic thrombocytopenic purpura
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This review provides diagnostic considerations and management approaches for common benign hematologic emergencies, including thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, disseminated intravascular coagulopathy, catastrophic antiphospholipid antibody syndrome, hemophagocytic lymphohistiocytosis, acute chest syndrome associated with sickle cell disease, and hyperhemolysis syndrome.
Hematologic conditions (malignant or benign) may progress to acute critical illness requiring prompt recognition and intensive management. This review outlines diagnostic considerations and approaches to management for intensivists of common benign hematologic emergencies, including the following: thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, disseminated intravascular coagulopathy, catastrophic antiphospholipid antibody syndrome, hemophagocytic lymphohistiocytosis, acute chest syndrome associated with sickle cell disease, and hyperhemolysis syndrome.
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