Journal
CHEST
Volume 161, Issue 5, Pages 1360-1369Publisher
ELSEVIER
DOI: 10.1016/j.chest.2022.01.033
Keywords
direct oral anticoagulant; off-label use; thromboembolism
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This article reviews the evidence and current off-label use of direct oral anticoagulants in various cardiopulmonary disease states.
Direct oral anticoagulants (DOACs) are increasingly used in clinical practice and have become essential in the management of atrial fibrillation and VTE. The enthusiasm for DOACs has fueled the off-label application of these agents in cardiopulmonary disease, and their use has often outpaced the evidence supporting their application. This article reviews the evidence and current off-label use of DOACs in various cardiopulmonary disease states.
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