Journal
CHEMOSPHERE
Volume 281, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2021.130739
Keywords
Graphene oxide; Antibacterial activity; Mechanism of action; Physicochemical characteristics; Cytotoxicity
Categories
Funding
- University of Malaya Impact Oriented Interdisciplinary Research Grants [IIRG003B-19FNW, IIRG018A-2019]
- RU SATU grant [ST003-2020]
- Fundamental Research Grant Scheme [FP023-2020]
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The recent advances in nanotechnology have led to increased use of nanomaterials in various fields. Graphene oxide (GO) shows promise as an antibacterial material, but further research is needed to fully understand its mechanism of action.
Recent advances in the field of nanotechnology contributed to the increasing use of nanomaterials in the engineering, health and biological sectors. Graphene oxide (GO) has great potentials as it could be fine-tuned to be adapted into various applications, especially in the electrical, electronic, industrial and clinical fields. One of the important applications of GO is its use as an antibacterial material due to its promising activity against a broad range of bacteria. However, our understanding of the mechanism of action of GO towards bacteria is still lacking and is often less described. Therefore, a comprehensive overview of bactericidal mechanistic actions of GO and the roles of physicochemical factors including size, aggregation, functionalization and adsorption behavior contributing to its antibacterial activities are described in this review. As the use of GO is expected to increase exponentially in the health sector, the cytotoxicity of GO among the cell lines is also discussed. Thus, this review emphasizes the physicochemical characteristics of GO that can be tailored for optimal antibacterial properties that is of importance to the health industry.
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