Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 28, Issue 8, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202104421
Keywords
biocatalysis; helical nanoribbons; peptides; post-assembly modifications; self-assembly; supramolecular hydrogels
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Funding
- KOSE Cosmetology Research Foundation
- Uehara Memorial Foundation
- JSPS Core-to-Core Program
- Life Science Research Center, Gifu University
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In this study, we demonstrated the construction of thermally stable supramolecular hydrogels through thermolysin-assisted biocatalysis, as well as the post-assembly modification of these structures using fluorescence imaging.
Aqueous self-assembly of short peptides has attracted growing attention for the construction of supramolecular materials for various bioapplications. Herein, we describe how the thermolysin-assisted biocatalytic construction of a dipeptide hydrazide from an N-protected amino acid and an amino acid hydrazide leads to the formation of thermally stable supramolecular hydrogels. In addition, we demonstrate the post-assembly modification of the supramolecular architectures constructed in situ tethering hydrazide groups as a chemical handle by means of fluorescence imaging.
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