Bioengineered Protein-based Adhesives for Biomedical Applications

Protein-based adhesives with their robust adhesion performance and excellent biocompatibility have been extensively explored over years. In particular, the unique adhesion behaviours of mussel and sandcastle worm inspired the development of synthetic adhesives. However, the chemical synthesized adhesives often demonstrate weak underwater adhesion performance and poor biocompatibility/biodegradability, limiting their further biomedical applications. In sharp contrast, genetically engineering endows the protein-based adhesives the ability to maintain underwater adhesion property as well as biocompatibility/biodegradability. Herein, we outline recent advances in the design and development of protein-based adhesives by genetic engineering. We summarize the fabrication and adhesion performance of elastin-like polypeptide-based adhesives, followed by mussel foot protein (mfp) based adhesives and other sources protein-based adhesives, such as, spider silk spidroin and suckerin. In addition, the biomedical applications of these bioengineered protein-based adhesives are presented. Finally, we give a brief summary and perspective on the future development of bioengineered protein-based adhesives.

Automated summary

Protein-based adhesives have been explored for biomedical applications due to their strong adhesion performance and excellent biocompatibility. Genetic engineering has enabled these adhesives to maintain underwater adhesion property as well as biocompatibility. Recent advances in this area include elastin-like polypeptide-based adhesives, mussel foot protein-based adhesives, and other protein sources like spider silk spidroin and suckerin. Bioengineered protein-based adhesives show promise for future development in biomedical applications.