Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 28, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103925
Keywords
alpha-ketoamides; alkynes; photo-affinity labeling; spin density; thiophenes
Categories
Funding
- PRIME from the Japan Agency for Medical Research and Development, AMED
- Platform Project for Supporting Drug Discovery and Life Science Research (BINDS) from the Japan Agency for Medical Research and Development, AMED
- JSPS KAKENHI [21K19053, 21H02070, 20K15957]
- Sumitomo Foundation
- Grants-in-Aid for Scientific Research [21K19053, 20K15957, 21H02070] Funding Source: KAKEN
Ask authors/readers for more resources
Minimalist photo-reactive probes, consisting of a photo-reactive group and a tag for detection of target proteins, are valuable tools in chemical biology. In this study, minimalist probes based on a 2-thienyl-substituted alpha-ketoamide with an alkyne group on the thiophene ring were developed. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.
Minimalist photo-reactive probes, which consist of a photo-reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine-based and aryl azide-based minimalist probes are available, no keto-based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2-thienyl-substituted alpha-ketoamide bearing an alkyne group on the thiophene ring. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
